From Karen Durbin's 2003 interview with director Alejandro Gonzalez Inarritu about his film 21 Grams:
"Life is an inevitable chain of losses since we are born. We lose the womb, our mothers, and we lose our childhood, and we lose our innocence, and we lose our friends in school, and we lose our dreams and our faith, and we lose our parents, and sometimes our jobs, and we lose our hair and our feet and our health, and in the end our life. But how do we confront that? How can we give meaning to our life even if that will happen, want it or not? These characters, there's a moment that they stop living and start surviving. And how can they return to life again? They learn something about themselves, they regain themselves. And that's the dignity of being human. I'm not trying to just put miserable people in miserable circumstances and a miserable ending. I think life is very bright and very beautiful, but it's also really dark and sometimes really frightening."